Adult chat lv
In search of potential sources for acetylcholine (ACh) in the LV niche, we uncovered direct cholinergic innervation from previously undescribed subependymal Ch AT) neurons.
These novel cholinergic neurons display morphological and functional differences from neighboring striatal counterparts, and releases ACh into the LV niche in activity-dependent fashion.
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It is generally believed that these local effects are responsible for sustaining neurogenesis, though behavioral paradigms and disease states have suggested possibilities for neural circuit-level modulation.
With recent experimental findings that neuronal stimulation can directly evoke responses in LV NSCs, it is possible that this exciting property will add a new dimension to identifying postnatal/adult NSCs. Identification of a neural stem cell in the adult mammalian central nervous system. doi: 10.1016/S0092-8674(00)80956-3 Pub Med Abstract | Cross Ref Full Text | Google Scholar Kirschenbaum, B., Doetsch, F., Lois, C., and Alvarez-Buylla, A. Adult subventricular zone neuronal precursors continue to proliferate and migrate in the absence of the olfactory bulb.
Our current models of postnatal/adult LV neurogenesis do not take into account local astrogenesis, or the possibility that cellular markers may be similar between non-dividing GFAP NSCs and their differentiated astrocyte daughters. T., Mirzadeh, Z., Soriano-Navarro, M., Rasin, M., Wang, D., Shen, J., et al. Postnatal deletion of Numb/Numblike reveals repair and remodeling capacity in the subventricular neurogenic niche. doi: 10.1016/20 Pub Med Abstract | Cross Ref Full Text | Google Scholar Lacar, B., Young, S.
Postnatal LV neurogenesis is regulated by NSC-intrinsic mechanisms interacting with extracellular/niche-driven cues.
Since we are taught that we can’t just upgrade our brains by replacing or adding new neurons, how does it keep up as we fill it with new experiences/tasks/skills?