Histamine complex dating
When mast cells are activated by allergens bound to immunoglobulin E antibodies, kinesin-1 (green) transports secretory granules containing histamine and other inflammatory factors to the cell periphery along microtubules (red).
Researchers in France have identified a molecular motor that controls the release of inflammatory factors that cause severe and fatal allergic reactions.
I suspect, however, that many people who complain of histamine intolerance don’t always have issues with the enzyme in particular.
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Anything that causes histamine to increase will contribute to this condition.
This well-conserved pocket with mostly hydrophobic nature contributes to the low selectivity of the first-generation compounds. expressed the receptor, prepared the membrane, and performed the ligand-binding assay.
The pocket is associated with an anion-binding region occupied by a phosphate ion.
Docking of various second-generation H, both of which form part of the anion-binding region.
This region is not conserved in other aminergic receptors, demonstrating how minor differences in receptors lead to pronounced selectivity differences with small molecules. collected the data and processed diffraction data with G.
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